AA << found that fate decision is not a unique programmed event, but the result of a very dynamic process composed of spontaneous fluctuation and selective stabilisation of alternative cellular states >>
<< The whole process is reminiscent of trial-and-error learning in which each cell explores—at its own rhythm and independently of cell division—different molecular possibilities (i.e. different genes turned on or off) before reaching a stable combination of active genes and the corresponding morphology >>
AA << observed that some cells seem to "hesitate" and change morphology many times before reaching a stable state >>
Which type of cell to become: Decision through indecision.
July 27, 2017
<< Individual cells take lineage commitment decisions in a way that is not necessarily uniform >>
AA << identifies a new category of cells with fluctuating phenotypic characteristics, demonstrating the complexity of the fate decision process >>
Alice Moussy, Jérémie Cosette, et al. Integrated time-lapse and single-cell transcription studies highlight the variable and dynamic nature of human hematopoietic cell fate commitment. PLoS Biol 15(7): e2001867 doi: 10.1371/journal.pbio.2001867
in pratica un lancio di dadi, ... quasi.
<< Amico, qualunque cosa suonerai . . . >>