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mercoledì 2 agosto 2017

# s-gst: the importance of noise (transcriptional noise) in stem cell. dev., by Wolf et al.

<< Random differences between cells early in development could be the key to making different cells in the body, according to new research from a team co-led by Professor Wolf Reik >>

<< when cells start specialising into different cell types their gene activity becomes more 'noisy' - each cell starts to turn different groups of genes on or off >>

Noise helps cells make decisions: Team reveals the importance of genetic noise in development. Aug 1, 2017

https://m.phys.org/news/2017-08-noise-cells-decisions-team-reveals.html

AA << study systematically charts transcriptional noise and uncovers molecular processes associated with early lineage decisions >>

Hisham Mohammed, Irene Hernando-Herraez, et al. Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation. Cell Reports , Volume 20 , Issue 5 , 1215 - 1228 doi: 10.1016/j.celrep.2017.07.009 Publ. Aug 1, 2017

http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30961-0

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